Provigil Dosage Chart for Adults (2025)
The standard Provigil dosage for adults is 200 mg once daily in the morning. Doses up to 400 mg/day are well tolerated, but no additional benefit beyond 200 mg has been proven.
| Condition | Starting Dose | Max Daily | Timing |
|---|---|---|---|
| Narcolepsy | 200 mg AM | 400 mg | Once daily, morning |
| Obstructive Sleep Apnea | 200 mg AM | 400 mg | Once daily, morning |
| Shift Work Disorder | 200 mg | 400 mg | 1 h before shift |
| MS Fatigue† | 200 mg AM | 400 mg | Once daily, morning |
100 mg vs 200 mg vs 400 mg – Which to Choose?
- 100 mg: starter dose, fewer side effects
- 200 mg: standard dose, best benefit/risk
- 400 mg: maximum, no extra benefit vs 200 mg.
How to Take Provigil – Step-by-Step
- Swallow tablet whole or split along the score line.
- Take with or without food (food delays peak by 1 h).
- Morning dose: before 10 AM to avoid insomnia.
- Shift-work: 1 h before start of shift.
- Do not double-dose if missed; take next morning.
Hepatic & Renal Adjustment – 2025 Guide
- Severe hepatic (Child-Pugh B/C): reduce to 100 mg once daily (50 % cut).
- Renal impairment (CrCl 20–90 mL/min): no adjustment needed.
- Geriatric (≥65 y): start 100 mg, monitor BP/HR.
Off-Label Uses – 2025 Data
- MS fatigue: 200–400 mg/day AM.
- Parkinson’s fatigue: 200 mg AM, max 400 mg.
- ADHD (adults): not recommended – trials failed vs placebo.
Pill ID – 100 mg vs 200 mg
- 100 mg: debossed "PROVIGIL" on one side, "100 MG" on the other.
- 200 mg: debossed "PROVIGIL" on one side, "200 MG" on the other.
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Frequently Asked Questions
Can I take 400 mg of Provigil at once?
Yes, 400 mg once daily is the maximum approved dose, but no extra benefit vs 200 mg was proven. Split 200+200 if side effects occur.
What happens if I miss a dose?
Skip the missed dose and take the next one at the usual time. Do not double to catch up – risk of insomnia.
Is Provigil dosage the same for depression fatigue?
Off-label: 200 mg AM, titrate to 400 mg based on response. Benefits may diminish after 2 weeks.
Do I need to taper Provigil?
No taper needed – stop abruptly safe. No withdrawal syndrome reported.