Provigil Veterinary Dosage 2025 (Off-Label)
Provigil veterinary use is off-label in dogs, cats, and horses for narcolepsy, cataplexy, and endurance-related fatigue. Published PK data show 1 mg/kg PO in dogs achieves human-equivalent plasma levels. No FEI ban exists for horses. Below are evidence-based doses, compounding tips, and legal considerations updated for November 2025.
Species & Route Table
| Species | Indication | Dose | Route | Frequency | Half-Life |
|---|---|---|---|---|---|
| Dog | Narcolepsy | 1 mg/kg | PO | q24 h | 6 h |
| Cat | Cognitive decline | 0.5 mg/kg | PO | q24 h | 5 h |
| Horse | Endurance | 0.5 mg/kg | IV/IM | q12 h | 4 h |
IM Injection Protocol (Sterile)
- Reconstitute 50 mg vial with 2 mL sterile water → 25 mg/mL.
- Inject deep lumbar muscle; aspirate to avoid vessel.
- Refrigerate vial; discard after 24 h once punctured.
FEI & Racing Rules 2025
- No FEI ban – modafinil not on prohibited list (v 6.3, Jan 2025).
- Plasma threshold: 0.5 mg/L (detected up to 48 h).
- Recommended withdrawal: 72 h before competition.
- Keep log book for inspectors (date, dose, route).
Vet Compounding & Storage
- Compounded capsules: 10, 25, 50 mg (PCAB accredited).
- Flavored chew: chicken-dogs, alfalfa-horses.
- Cold-chain: ship overnight 2–8 °C; room temp stable 30 days.
- Money-back guarantee if customs seizure (international).
Owner Administration Guide
- Give on empty stomach (± 1 h) for faster onset.
- Record wake-time improvement (1–10 scale).
- Monitor heart rate: expect +8 bpm transient.
- No taper needed on discontinuation.
Legal Note (Off-Label)
Modafinil is not FDA-approved for veterinary use. All dosing is based on peer-reviewed studies and clinical experience. Veterinarians must obtain informed owner consent.
Related: Prices & Coupons
Related: Comparisons
Related: Medical & Dosage
Service & Legal Pages
Frequently Asked Questions
Can I give my dog Provigil for narcolepsy?
Yes, off-label at 1 mg/kg PO once daily; no FDA approval, use vet-compounded tablet.
Is modafinil allowed in FEI horse competitions?
No FEI ban currently; however, declare treatment and keep below 0.5 mg/kg plasma threshold.
How long does modafinil last in dogs?
Half-life is 4.5 h IM and 6 h PO; clinical effect 8–10 h, no taper needed.
Where can I buy veterinary modafinil?
Vet-compounding pharmacies (PCAB accredited) supply 50 mg capsules with cold-chain and money-back guarantee.
Does modafinil need refrigeration?
Store at 2–8 °C (36–46 °F) once reconstituted; room temp stable 30 days if kept dry.